Corrigendum: A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition
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This Article contains an error in Figure 2c, where the y-axis 'μ g [Ru]/mg [cell protein]' is incorrectly labelled as 'ng [Ru]/mg [cell protein]'. The correct Figure 2c appears below as Figure 1.
منابع مشابه
A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition
Ruthenium(II) polypyridyl complexes can intercalate DNA with high affinity and prevent cell proliferation; however, the direct impact of ruthenium-based intercalation on cellular DNA replication remains unknown. Here we show the multi-intercalator [Ru(dppz)2(PIP)](2+) (dppz = dipyridophenazine, PIP = 2-(phenyl)imidazo[4,5-f][1,10]phenanthroline) immediately stalls replication fork progression i...
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Substitutionally inert ruthenium(II) polypyridyl complexes have been developed as DNA intercalating agents yet cellular DNA damage responses to this binding modality are largely unexplored. Here, we show the nucleartargeting complex [Ru(phen)2(tpphz)] 2+ (phen 1⁄4 1,10-phenanthroline, tpphz 1⁄4 tetrapyridophenazine) generates rapid and pronounced stalling of replication fork progression in p53-...
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